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KMID : 0359319930330020211
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Korean Journal of Veterinary Research
1993 Volume.33 No. 2 p.211 ~ p.216
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Effect of cholinergic and α2 - adrenergic nerve on the isolated dog ileal smooth muscle by the electrical field stimulation
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Abstract
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To elucidate the action of the cholinergic and α₂-adrenergic nerve on the isolated ileal smooth muscle of the dog, effect a of electrical field stimulation were investigated on the pretreatment of the physostigmine ; cholinestrase inhibitor, yohimbue ; α₂-adrenoceptor blocker, atropine ; cholinergic receptor blocker and phentolatnine ; non-selective α₂-adrenoceptor blocker from physiograph.
1. The contractile response induced by electrical field stimulation was the frequency (2-40Hz) α₂-dependent manner.
2. The contractile response induced by electrical field stimulation was markedly increased by the pretreafment of physostigmine(1μM) ; cholinestrase inhibitor.
3. The contractile response induced by electrical field stimulation was increased by the pretreatment of yohimbine(lμM) ; α₂-adrenoceptor blocker.
These finding suggest that it was powerful excitatory action by cholinergic nerve and inhibitory action by α₂-adrenergic nerve on ileal smooth muscle of the dog.
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